Intracranial Pathology: Brain Tumors, ICP, and Abscess Management
Increased Intracranial Pressure (ICP)
The skull is a rigid compartment. Any added volume (tumor, blood, edema, or CSF) raises the Intracranial Pressure (ICP). ICP is considered elevated when it is greater than 20 mmHg (normal is typically less than 15 mmHg).
The relationship between ICP and Cerebral Perfusion Pressure (CPP) is critical: CPP = MAP − ICP. A rising ICP reduces CPP, leading to cerebral ischemia.
Causes of Elevated ICP
- Intracranial mass (tumor, hematoma, large infarct)
- Cerebral edema
- Hydrocephalus
Stem Cell Regulation, Cancer Therapy, and Genetic Modification Techniques
Cancer Stem Cells and Therapeutic Strategies
Normal Stem Cells Versus Cancer Stem Cells
Normal stem cells self-renew in a controlled way to maintain tissues, while cancer stem cells (CSCs) self-renew uncontrollably and form tumors. CSCs resist therapy and can regenerate the tumor, unlike normal stem cells whose growth is tightly regulated.
Characteristics of Cancer Stem Cells
CSCs can self-renew, differentiate into different tumor cell types, and initiate new tumors. They express markers like CD44,
Read MoreStem Cell Niches, Activation, Therapies & Risks
Drosophila Ovary — Germarium
Female (Ovary — Germarium)
Female (Ovary – Germarium):
In the Drosophila ovary, 2–3 germline stem cells (GSCs) are located at the anterior tip of the germarium. They physically attach to cap cells using E-cadherin–mediated adhesion. Cap cells act as the niche, producing key signals such as Dpp, Gbb, Hedgehog, and Piwi to maintain GSC self-renewal.
When a GSC divides, it undergoes asymmetric division: one daughter remains attached to cap cells and stays a stem cell,
Read MoreClinical Shock: Diagnosis, Physiology, and Treatment
Understanding Clinical Shock
Shock is one of the most frequently diagnosed and most complex clinical conditions encountered in the critically ill patient. Ongoing investigations have identified the mechanisms of various shock states to be complicated, yet based within the cellular foundation of normal, everyday existence. Although mortality from shock states remains high, the focus on early, aggressive resuscitation to defined endpoints has significantly enhanced a clinician’s ability to improve
Read MoreUnderstanding the Immune System and Autoimmunity
Understanding the Immune System
The immune system is the body’s natural defense against infection. Through a series of steps, your body fights off invading infectious organisms and destroys them before they cause harm. When your immune system is functioning properly, it protects against infections that cause disease.
Scientists have begun to understand the immune system in detail. Researchers are continually generating more information on its operation and what happens when it malfunctions.
The Immune
Read MoreMedical Laser Technology: Applications, Techniques, and Safety
This document provides a detailed explanation of the technique, applications, indications, and contraindications of laser use in medicine and surgery.
Laser Technology in Medicine and Surgery
What Is a Laser?
LASER is an acronym that stands for: Light Amplification by Stimulated Emission of Radiation.
Lasers emit coherent, monochromatic, and collimated light, which can be precisely focused on tissues. The interaction of laser energy with biological tissues—ranging from cutting and vaporizing to coagulating
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