Herbal Drug Evaluation: WHO, ICH, and GMP Standards
Evaluation of Drugs
WHO Guidelines for Evaluation of Drugs
The World Health Organization (WHO) has provided specific guidelines to ensure that herbal and crude drugs are safe, effective, and of good quality.
Because herbal drugs come from natural sources, their quality may vary due to climate, soil, collection methods, processing, and storage. Therefore, WHO guidelines help in the standardization, quality control, safety, and efficacy evaluation of crude drugs.
Objectives of WHO Guidelines
- To ensure
Irrigation Management and Hydraulic Calculations
Flow and Measurement
- Velocity = Distance / Time
- Q = V × A
- Q = Flow Rate
- V = Velocity
- A = Area
Evapotranspiration and Scheduling
- ETc = ETo × Kc
Irrigation Efficiency
- IE (%) = (Beneficial Water Used / Total Applied) × 100
Application Efficiency
- AE (%) = (Water Reaching Target / Water Applied) × 100
Available Water Holding Capacity
- AWHC = FC − PWP
Maximum Soil Moisture Depletion
- SMDmax = AWHC × Root Zone × MAD
Gross Irrigation Depth
- Gross Depth = Net Depth / IE
Volume Calculations
- Volume = Area × Depth
Key Soil
Read MoreHistory and Evolution of the Pharmacy Profession in India
History of the Pharmacy Profession in India
Pharmacy education in India at the certificate level was started in 1842 in Goa by the Portuguese. Formal training of compounds began in 1881 in Bengal, and as a university-level program in 1937 at the Banaras Hindu University (Varanasi). In Baghdad, the first pharmacies or drug stores were established in 754.
The revolution in science and technology post-World War II triggered a change in the pharmacy profession. As pharmacy is a healthcare profession,
Read MoreEssential Building Acoustics and Lighting Principles
Sound Insulation Principles
Introduction: Sound insulation prevents unwanted sound transmission between spaces.
- Definition: The ability of a building element to reduce sound transmission from one space to another.
- Objectives: Noise reduction, privacy, and acoustic comfort.
- Methods: Thick walls, double walls, cavity walls, air gaps, double glazing, acoustic doors, and floating floors.
- Factors: Mass, thickness, density, airtightness, and construction quality.
- Applications: Hospitals, hotels, offices, libraries,
Chemical Engineering Principles: Drying, Distillation, and Evaporation
Constant Rate Drying Equation Derivation
To derive the equation for constant-rate drying considering conduction, convection, and radiation, we perform an energy balance where the heat flux q” (W/m²) is the sum of all heat transfer modes.
Step 1: Moisture Flux
From drying theory, the drying rate N is defined as:
N = -(Ws/a)(dX/dt)
For constant-rate drying, N is constant, leading to:
t = (Ws/aN)(Xi – Xf)
Step 2: Energy Balance
The moisture evaporation rate is controlled by the heat supply:
N = q”/λ
Where
Read MoreEnergy Conservation and Management Exam Answers
ECM 2024 Exam Answers
Q2(a): Energy Definition and Classification
Definition: Energy is the capacity to do work. It cannot be created or destroyed (Law of Conservation of Energy), only converted from one form to another.
Classification of Energy:
- Based on Source:
- Conventional Energy — Coal, petroleum, natural gas, nuclear. Widely traded and commercially used.
- Non-Conventional (Renewable) Energy — Solar, wind, tidal, biomass, geothermal. Inexhaustible and eco-friendly.
- Based on Form:
- Mechanical Energy